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European Spallation Source

The European Spallation Source (ESS) is a European Research Infrastructure Consortium (ERIC), based around what will be the world’s most powerful neutron source. Located in Lund, Sweden, the facility will produce its first neutrons in 2025 and will begin a user program in 2027. The Deuteration and Macromolecular Crystallisation (DEMAX) platform, part of the Scientific Activities Division, is comprised of chemical and biological deuteration and support for protein crystallisation. The chemical deuteration laboratory focuses on the synthesis of novel, complex, deuterated small molecules for neutron users, in collaboration with the other Deuteration Network (DEUNET) partner institutions. The biological deuteration and crystallisation laboratory of ESS is co-housed with the Lund Protein Production Platform (LP3), within Lund University.

Deuteration capabilities

  • E. coli (cell paste, recombinant protein, plasmid DNA)
  • Botryococcus braunii (cell paste, algal cell extract for media preparation)
  • P. pastoris (phospholipids, total lipid extracts)
  • Hydrothermal pressure reactors (Parr)
  • Synthetic chemistry
  • Enzyme-assisted synthesis
  • Support for large crystal growth (proteins)
Key molecules

User access

User program

Pilot calls currently, aim for 1 call per year from 2027. Proposal based, peer reviewed with access awarded based on scientific excellence. Submissions via ESS user office.

Access modes

Access available to anyone based on scientific merit, not country of origin.



European Spallation Source (ESS)


Group Leader for Deuteration and Macromolecular Crystallisation