National Deuteration Facility
ANSTO
ANSTO’s National Deuteration Facility (NDF) is the only facility of its type in the Southern Hemisphere with the expertise and infrastructure to produce deuterated molecules through both biological and chemical techniques. The NDF produces bespoke deuterated molecules to enhance contrast in complex systems studied using neutron scattering instruments or by using spectroscopic techniques such as NMR, IR or MS, enabling investigations of molecular structure and function and enhanced properties of new materials. Located in Sydney, Australia, the NDF is able to provide a wide diversity of deuterated molecules for researchers and industry worldwide. The NDF is partly supported by the National Collaborative Research Infrastructure Strategy – an initiative of the Australian Government.
Deuteration capabilities
- E. coli recombinant protein expression (biomass, purified protein)
- Yeast (e.g. S. cerevisiae for cholesterol production)
- Other microbial systems
- Hydrothermal pressure reactors (Parr)
- Synthetic chemistry
- Microwave synthesis
NDF is located on same site as the Australian Centre for Neutron Scattering (ACNS). Combined proposal to access both facilities available.
Specialities
- Per-deuterated lipids
- Phospholipids
- Carboxylic acids and derivatives
- Aromatic compounds
- Sugars
- Ionic compounds
- Glycols
- Glycerides
- Biopolymers
- Proteins
Key molecules
- Detergents – “invisible” (e.g. DDM)
- Lipids – perdeuterated and specifically deuterated oleic and linoleic lipid derivatives
- Proteins - deuterated and multiple-labelled (2H,13C,15N)
- Cholesterol-d45
- OLED compounds
User access
User program
Yes
Formal call for proposals twice per year (mid-March and mid-September) Access available to anyone via the submission portal.
Access modes
Merit
User Pays/Collaborative
Commercial
Details
Address
Australian Nuclear Science and Technology Organisation (ANSTO)
New Illawarra Rd
Lucas Heights
NSW
2234
Australia