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National Deuteration Facility


ANSTO’s National Deuteration Facility (NDF) is the only facility of its type in the Southern Hemisphere with the expertise and infrastructure to produce deuterated molecules through both biological and chemical techniques. The NDF produces bespoke deuterated molecules to enhance contrast in complex systems studied using neutron scattering instruments or by using spectroscopic techniques such as NMR, IR or MS, enabling investigations of molecular structure and function and enhanced properties of new materials. Located in Sydney, Australia, the NDF is able to provide a wide diversity of deuterated molecules for researchers and industry worldwide. The NDF is partly supported by the National Collaborative Research Infrastructure Strategy – an initiative of the Australian Government.

Enabled by:

Deuteration capabilities

  • E. coli recombinant protein expression (biomass, purified protein)
  • Yeast (e.g. S. cerevisiae for cholesterol production)
  • Other microbial systems
  • Hydrothermal pressure reactors (Parr)
  • Synthetic chemistry
  • Microwave synthesis

NDF is located on same site as the Australian Centre for Neutron Scattering (ACNS). Combined proposal to access both facilities available.

Key molecules

User access

User program

Formal call for proposals twice per year (mid-March and mid-September) Access available to anyone via the submission portal.

Access modes
User Pays/Collaborative



Australian Nuclear Science and Technology Organisation (ANSTO)
New Illawarra Rd
Lucas Heights


NDF Leader NDF

Karyn Wilde
NDF User Program Manager