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ILL Deuteration Laboratory

Institut Laue-Langevin

The Deuteration Laboratory (D-Lab) is run as a user platform and is part of the ILL Life Sciences Group in Grenoble, France. It allows users in the area of life sciences and structural biology to seek tailor-made deuterated biomolecules in support of neutron scattering, protein crystallography, dynamics and reflectometry. The D-Lab is one of the many technical platforms of the Partnership for Structural Biology (PSB) located on the EPN campus in Grenoble.

Deuteration capabilities

  • Recombinant protein expression in bacteria and yeast
  • Deuteration of whole organisms (bacteria, yeast, algae)
  • Peptide synthesis by solid phase
  • Expertise in large crystal growth
  • Labelled biomass, from which the target biomolecule can be extracted, is supplied to the user.
  • Some purified model proteins can be requested : Maltose-Binding Protein, Human Serum Albumin, Myoglobin, Pfu Rubredoxin, Alpha-synuclein, Lysozyme.
  • Small deuterated molecule of biological interest (cholesterol, campesterol) produced in vivo.
  • The D-lab is providing the biomass to the ILL Lipid-Lab for the purification of lipids.
Key molecules

User access

User program

There is no call for D-Lab proposal applications and these can be submitted at any time during the year. Applicants should contact the D-Lab team before submitting proposals to discuss technical feasibility.

Access modes
Peer review

Access to the D-Lab is gained through a rapid peer-review proposal system and open to all the ILL member countries, regardless of where the neutron scattering study is carried out. It is also available to users from non-member countries - although a contribution to the costs may be requested.



Institut Laue-Langevin
CIBB building
Campus EPN